Bromobenzene-induced zonal necrosis in the hepatic acinus
نویسندگان
چکیده
منابع مشابه
Bromobenzene-induced zonal necrosis in the hepatic acinus.
The time course and acinar distribution of bromobenzene-induced hepatic necrosis was studied in the rat. Cellular damage, lipid infiltration, and changes in glycogen deposits were investigated by light microscopy 6, 16, 24, and 48 hr after bromobenzene (BZ) administration. Concomitantly, ultrastructural changes were followed by electron microscopy in each zone of the acinus. To insure accurate ...
متن کاملBromobenzene-induced hepatotoxicity at the transcriptome level.
Rats were exposed to three levels of bromobenzene, sampled at 6, 24, and 48 h, and liver gene expression profiles were determined to identify dose and time-related changes. Expression of many genes changed transiently, and dependent on the dose. Few changes were identified after 6 h, but many genes were differentially expressed after 24 h, while after 48 h, only the high dose elicited large eff...
متن کاملProtective Effects of Berberine on Bromobenzene-Induced Nephrotoxicity in Mice
Introduction: Bromobenzene is an environmental toxin whose metabolites cause renal toxicity. The mechanism involved in toxicity includes oxidative stress. The aim of this study was to investigate the protective effects of berberine against bromobenzene-induced renal toxicity in male NMRI mice. Materials and Methods: In this experimental study, subjects were divided into five groups. Group I...
متن کاملAplastic anaemia and severe hepatic zonal necrosis after anti-syphilitic treatment.
A married man aged 53 reported to the venereal diseases clinic in March, 1949, when he was found to have syphilis with an early secondary rash. A penile sore was present, and the Wassermann reaction was strongly positive. Treatment with Stabilarsan and bismuth was begun, and he received a total of 16-2 g. of the former, and 5 7 g. of the latter (a normal course) between March, 1949, and January...
متن کاملAcute Hepatic Necrosis Induced by Brucella Infection in Hyperthyroid Mice
When small numbers of Brucella melitensis were inoculated into ABC mice, occasional hepatic granulomas without necrosis were demonstrated. The greatest multiplication of brucellae was detected in the spleens. Because it had been previously observed that ACTH or cortisone markedly accelerated the multiplication of brucellae in the livers of infected mice with destruction of liver cells, it was c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Experimental and Molecular Pathology
سال: 1978
ISSN: 0014-4800
DOI: 10.1016/0014-4800(78)90078-3